abstract：:Using immunofluorescence and real 3-D confocal microscopy, our results showed the presence of ET-1, ETA, and ETB receptors in isolated human aortic vascular endothelial cells (hVECs). The level of the peptide and its receptors was significantly higher in the nucleus (including the nuclear envelope membranes) than in t...

journal_title：Canadian journal of physiology and pharmacology

authors： Avedanian L,Riopel J,Bkaily G,Nader M,D'Orleans-Juste P,Jacques D

更新日期：2010-08-01 00:00:00

abstract：:After myocardial infarction, the hemodynamics under basal conditions might appear to be unaltered, which makes it difficult to identify cardiac dysfunction by the usual approaches. Thus, we tested the response to sudden afterload stress in infarcted rats with apparently normal ejection function. Control (CT) and infar...

journal_title：Canadian journal of physiology and pharmacology

authors： dos Santos L,Antonio EL,Souza AF,Tucci PJ

更新日期：2010-07-01 00:00:00

abstract：:Inactivation of endothelin B receptors (ETB), either through selective pharmacological antagonism or genetic mutation, increases the circulating concentration of endothelin-1 (ET-1), suggesting ETB plays an important role in clearance of this peptide. However, the cellular site of ETB-mediated clearance has not yet be...

journal_title：Canadian journal of physiology and pharmacology

authors： Kelland NF,Kuc RE,McLean DL,Azfer A,Bagnall AJ,Gray GA,Gulliver-Sloan FH,Maguire JJ,Davenport AP,Kotelevtsev YV,Webb DJ

更新日期：2010-06-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent vasoactive peptide that exerts hypertrophic, migratory, and mitogenic effects in vascular smooth muscle cells. ET-1-induced activation of several signaling events has been shown to mediate the cellular effects of ET-1. In the past several years, transactivation of growth factor receptor...

journal_title：Canadian journal of physiology and pharmacology

authors： Bouallegue A,Vardatsikos G,Srivastava AK

更新日期：2010-05-01 00:00:00

abstract：:Raloxifene (RLX), a selective oestrogen receptor modulator, has oestrogen-agonist effects on bone, lipoproteins, and homocysteine and oestrogen-antagonist activity in the breast and uterus, positioning it as a potential drug for long-term prevention of coronary heart disease in postmenopausal women. To further evaluat...

journal_title：Canadian journal of physiology and pharmacology

authors： Boudjeltia KZ,Durez P,Oberweis D,Guillaume M,Remacle C,Cauchie P,Vanhaeverbeek M,Brohée D,Ducobu J,Gregoir C

更新日期：2010-05-01 00:00:00

abstract：:Previous reports demonstrated that cilostazol, a phosphodiesterase 3 inhibitor, affected cellular electrophysiology and reduced episodes of ventricular fibrillation (VF) in patients with Brugada syndrome. However, its effects on VF induction and defibrillation efficacy have never been investigated. We tested the hypot...

journal_title：Canadian journal of physiology and pharmacology

authors： Kanlop N,Shinlapawittayatorn K,Sungnoon R,Weerateerangkul P,Chattipakorn S,Chattipakorn N

更新日期：2010-04-01 00:00:00

abstract：:Cardiac dysfunction due to ischemia-reperfusion (I/R) is associated with marked changes in membrane function and subsequent Ca2+-handling abnormalities in cardiomyocytes. The membrane abnormalities in hearts subjected to I/R arise primarily from oxidative stress as a consequence of increased formation of reactive oxyg...

journal_title：Canadian journal of physiology and pharmacology

authors： Tappia PS,Asemu G,Rodriguez-Leyva D

更新日期：2010-03-01 00:00:00

abstract：:Acrolein, a highly reactive alpha,beta-unsaturated aldehyde, is an omnipresent environmental pollutant. Chronic and acute human exposures occur through exogenous and endogenous sources, including food, vapors of overheated cooking oil, house and forest fires, cigarette smoke, and automobile exhaust. Acrolein is a toxi...

journal_title：Canadian journal of physiology and pharmacology

authors： Roy J,Pallepati P,Bettaieb A,Averill-Bates DA

更新日期：2010-03-01 00:00:00

abstract：:The leaves and bark of Cassia glauca Lam., a glabrous tree in the family Fabaceae, are used in folk medicine for the treatment of diabetes. The aim of this study was to investigate the antidiabetic activity of the aqueous extract of C. glauca bark. The various parameters that were studied in treated or untreated normo...

journal_title：Canadian journal of physiology and pharmacology

authors： Salahuddin M,Jalalpure SS,Gadge NB

更新日期：2010-02-01 00:00:00

abstract：:Hedysarum polybotrys polysaccharide (HPS) is the principal active fraction responsible for the antidiabetic properties of this species. The aim of this study was to determine the antidiabetic properties of 4 purified fractions of different molecular weight range HPSs (HPS1, HPS2, HPS3, HPS4). HPS3 was selected for exa...

journal_title：Canadian journal of physiology and pharmacology

authors： Hu F,Li X,Zhao L,Feng S,Wang C

更新日期：2010-01-01 00:00:00

abstract：:We have recently shown that vasoactive peptides such as angiotensin II (Ang II) and endothelin-1 (ET-1) increased the expression of G(i) proteins and proliferation of A10 vascular smooth muscle cells (VSMC) through MAP kinase / PI3 kinase pathways. The present study was undertaken to examine the implication of growth ...

journal_title：Canadian journal of physiology and pharmacology

authors： Gomez Sandoval YH,Lévesque LO,Anand-Srivastava MB

更新日期：2009-12-01 00:00:00

abstract：:Cerebrocrast is a novel lipophilic dihydropyridine derivative with potential neuroprotective and antidiabetic properties. We have analyzed its interaction with L-type (CaV1.2b) and T-type (CaV3.1) calcium channels using a whole-cell patch clamp in HEK 293 cells. Cerebrocrast inhibited current flux through both CaV1.2b...

journal_title：Canadian journal of physiology and pharmacology

authors： Drígelová M,Tarabová B,Duburs G,Lacinová L

更新日期：2009-11-01 00:00:00

abstract：:Recent studies demonstrate the critical role of the extracellular matrix in the organization of parenchymal cells in the heart. Thus, an understanding of the modes of regulation of matrix production by cardiac myofibroblasts is essential. Transforming growth factor beta (TGF-beta) signaling is transduced through the c...

journal_title：Canadian journal of physiology and pharmacology

authors： Cunnington RH,Nazari M,Dixon IM

更新日期：2009-10-01 00:00:00

abstract：:Space travelers experience anorexia and body weight loss in a microgravity environment, and microgravity-like situations cause changes in hypothalamic activity. Hypothalamic melanocortins play a critical role in the regulation of metabolism. Therefore, we hypothesized that microgravity affects metabolism through alter...

journal_title：Canadian journal of physiology and pharmacology

authors： Lew PS,Wong D,Yamaguchi T,Leckstrom A,Schwartz J,Dodd JG,Mizuno TM

更新日期：2009-10-01 00:00:00

abstract：:The expression of tissue factor (TF) in tumors reportedly exacerbates the aggressiveness of several types of cancers. The shedding of TF-containing membrane particles is believed to influence the ability of tumors to expand and metastasize, and these microparticles may also be harmful in the onset of disseminated intr...

journal_title：Canadian journal of physiology and pharmacology

authors： Brousseau C,Morissette G,Fortin JP,Marceau F,Petitclerc E

更新日期：2009-09-01 00:00:00

abstract：:Obesity is associated with autonomic nervous system dysfunction. The aim of the study was to evaluate baroreflex sensitivity, an indicator of autonomic nervous function, in 20 obese children and adolescents in comparison with 20 age- and sex-matched nonobese subjects. All subjects were examined in the supine position ...

journal_title：Canadian journal of physiology and pharmacology

authors： Lazarova Z,Tonhajzerova I,Trunkvalterova Z,Brozmanova A,Honzíková N,Javorka K,Baumert M,Javorka M

更新日期：2009-07-01 00:00:00

abstract：:Continuous exposure to nitroglycerin (GTN) results in development of tolerance and is associated with increased free radical production and abnormal endothelial function. Elevated plasma biomarkers of inflammation have been shown to be associated with endothelial dysfunction in most cardiovascular conditions. It remai...

journal_title：Canadian journal of physiology and pharmacology

authors： Thomas GR,DiFabio JM,Gori T,Jenkins DJ,Parker JD

更新日期：2009-06-01 00:00:00

abstract：:We examined the interaction of smooth muscle myosin with alpha-actin and beta-actin isoforms during the contraction of A7r5 smooth muscle cells and rat aortic smooth muscle. The techniques of confocal microscopy and fluorescence resonance energy transfer (FRET) analysis were utilized in examining A7r5 cells and rat ao...

journal_title：Canadian journal of physiology and pharmacology

authors： Black J,Dykes A,Thatcher S,Brown D,Bryda EC,Wright GL

更新日期：2009-05-01 00:00:00

abstract：:In sepsis, systemic inflammatory response syndrome (SIRS), and multiorgan dysfunction syndrome (MODS), a severe prognostically relevant cardiac autonomic dysfunction exists, as manifested by a strong attenuation of sympathetically and vagally mediated heart rate variability (HRV). The mechanisms underlying this attenu...

journal_title：Canadian journal of physiology and pharmacology

authors： Werdan K,Schmidt H,Ebelt H,Zorn-Pauly K,Koidl B,Hoke RS,Heinroth K,Müller-Werdan U

更新日期：2009-04-01 00:00:00

abstract：:Altered sympathetic nervous activity has been linked to the development and persistence of obesity, partly relating to overfeeding. Binding of the selective, positron-emitting phosphodiesterase-4 (PDE4) inhibitor (R)-[11C]rolipram provides a direct index of the cAMP-hydrolyzing enzyme PDE4. This study examines progres...

journal_title：Canadian journal of physiology and pharmacology

authors： Greene M,Thackeray JT,Kenk M,Thorn SL,Bevilacqua L,Harper ME,Beanlands RS,Dasilva JN

更新日期：2009-03-01 00:00:00

abstract：:Diabetic patients have a higher incidence of cardiac arrhythmias, including ventricular fibrillation and sudden death, and show important alterations in the electrocardiogram, most of these related to the repolarization. In myocytes isolated from diabetic hearts, the transient outward K+ current (Ito) is the repolariz...

journal_title：Canadian journal of physiology and pharmacology

authors： Gallego M,Alday A,Urrutia J,Casis O

更新日期：2009-02-01 00:00:00

abstract：:Aside from its established immunologic and hematologic functions, the spleen also plays an important role in cardiovascular regulation. This occurs through changes in intrasplenic microvascular tone, as well as through splenic neurohormonal modulation of the renal and mesenteric vascular beds. Splenic regulation of bl...

journal_title：Canadian journal of physiology and pharmacology

authors： Hamza SM,Kaufman S

更新日期：2009-01-01 00:00:00

abstract：:Beneficial effects of an antioxidant (N-acetyl-L-cysteine, NAC) and an angiotensin I-converting enzyme (ACE) inhibitor (ramipril) were assessed in a rat model of insulin resistance induced by 10% glucose feeding for 20 weeks. Treatments with NAC (2 g/kg per day) and ramipril (1 mg/kg per day) were initiated at 16 week...

journal_title：Canadian journal of physiology and pharmacology

authors： El Midaoui A,Ismael MA,Lu H,Fantus IG,de Champlain J,Couture R

更新日期：2008-11-01 00:00:00

abstract：:This study was conducted to examine the protective role of crude polysaccharide from brown seaweed Sargassum polycystum against acetaminophen-induced abnormality in blood glucose, serum albumin/globulin ratio, and liver glycogen, lactate, and pyruvate. Liver and renal tissue histology was performed to confirm the effi...

journal_title：Canadian journal of physiology and pharmacology

authors： Raghavendran HR,Srinivasan P

更新日期：2008-10-01 00:00:00

abstract：:Heme plays a critical role in blood pressure regulation because it is required by a number of enzymes that synthesize vascular modulators, including nitric oxide (NO), carbon monoxide (CO), guanosine 3',5'-cyclic monophosphate (cGMP), endothelium-derived hyperpolarizing factor (EDHF), and prostacyclin. The goal of thi...

journal_title：Canadian journal of physiology and pharmacology

authors： Soong J,Adams MA,Nakatsu K

更新日期：2008-09-01 00:00:00

abstract：:G protein-coupled receptors (GPCRs), including endothelin receptor A (ETA) and B (ETB), may form dimers or higher-order oligomers that profoundly influence signaling. Here we examined a PDZ finger motif within the C-terminus of ETA and its role in heterodimerization with ETB, and in homodimerization with itself, when ...

journal_title：Canadian journal of physiology and pharmacology

authors： Evans NJ,Walker JW

更新日期：2008-08-01 00:00:00

abstract：:In vivo fatty acid synthesis and the pathways of glycerol-3-phosphate (G3P) production were investigated in brown adipose tissue (BAT) from rats fed a cafeteria diet for 3 weeks. In spite of BAT activation, the diet promoted an increase in the carcass fatty acid content. Plasma insulin levels were markedly increased i...

journal_title：Canadian journal of physiology and pharmacology

authors： Chaves VE,Frasson D,Martins-Santos ME,Navegantes LC,Galban VD,Garófalo MA,Kettelhut IC,Migliorini RH

更新日期：2008-07-01 00:00:00

abstract：:Hyperglycemia in diabetes induces increased endothelin-1 (ET-1) production in the retina, kidney, and heart that may lead to hemodynamic impairment, permeability alteration, and increased extracellular matrix (ECM) protein production. Chronically elevated blood glucose levels may cause oxidative stress in these target...

journal_title：Canadian journal of physiology and pharmacology

authors： Chiu J,Xu BY,Chen S,Feng B,Chakrabarti S

更新日期：2008-06-01 00:00:00

abstract：:Gemcitabine, a nucleoside analogue for treating lung cancer, is clinically administered as an intravenous infusion. To achieve better patient compliance and more direct effect on the lung, we explored a new gemcitabine pulmonary delivery route and evaluated the pharmacokinetics and acute lung injury aspects in animals...

journal_title：Canadian journal of physiology and pharmacology

authors： Min R,Li T,Du J,Zhang Y,Guo J,Lu WL

更新日期：2008-05-01 00:00:00

abstract：:Malnutrition and inflammation are associated with end-stage renal disease (ESRD). Interleukin (IL)-6 and tumor necrosis factor alpha (TNF-alpha) powerfully predict death from cardiovascular disease. The aim of our study was to establish an association between markers of inflammation and parameters of malnutrition in p...

journal_title：Canadian journal of physiology and pharmacology

authors： Perunicic-Pekovic G,Pljesa S,Rasic-Milutinovic Z,Stankovic S,Ilic M,Maletic R

更新日期：2008-04-01 00:00:00

abstract：:The aim of the present study was to investigate the protective effect of total flavones of rhododendra (TFR) pharmacological preconditioning against myocardial ischemia-reperfusion (I/R) injury and its probable mechanisms in rats. Rat myocardial I/R injury was induced by ligating and untying the left anterior descendi...

journal_title：Canadian journal of physiology and pharmacology

authors： Zhang JH,Chen ZW,Wu Z

更新日期：2008-03-01 00:00:00

abstract：:Gripp-Heel is a homeopathic preparation frequently used in the treatment of respiratory viral infections such as various types of influenza and the common cold. The antiviral activity of Gripp-Heel was studied in vitro on human pathogenic enveloped and nonenveloped RNA and DNA viruses. Before the antiviral assays, in ...

journal_title：Canadian journal of physiology and pharmacology

authors： Glatthaar-Saalmüller B

更新日期：2007-11-01 00:00:00

abstract：:Eight pure triterpenoid saponin compounds isolated from the root of Polygala senega L., a plant indigenous to the Canadian prairies, were evaluated for their immunological activity in mouse models. The specific antibody responses of the IgG2a subclass increased significantly when isolated P. senega saponins were used ...

journal_title：Canadian journal of physiology and pharmacology

authors： Katselis GS,Estrada A,Gorecki DK,Barl B

更新日期：2007-11-01 00:00:00

abstract：:This study aimed to investigate the interrelationship of plasma lipid profile, lipid peroxidation, and erythrocyte antioxidative defense in patients with insulin-dependent (IDDM) and non-insulin-dependent (NIDDM) diabetes mellitus. Plasma levels of total cholesterol, triglycerides, and lipid peroxides and the activiti...

journal_title：Canadian journal of physiology and pharmacology

authors： Cimbaljević B,Vasilijević A,Cimbaljević S,Buzadzić B,Korać A,Petrović V,Janković A,Korać B

更新日期：2007-10-01 00:00:00

abstract：:We investigated the effect of Ginkgo biloba extracts and some of its individual constituents on the oxidative metabolism of valproic acid (VPA) in hepatic microsomes from donors with the CYP2C9*1/*1 genotype. G. biloba extract decreased 4-ene-VPA, 3-OH-VPA, 4-OH-VPA, and 5-OH-VPA formation with mean (+/- SE) IC50 valu...

journal_title：Canadian journal of physiology and pharmacology

authors： Numa AM,Abbott FS,Chang TK

更新日期：2007-09-01 00:00:00

abstract：:In Canada, the use of botanical natural health products (NHPs) for anxiety disorders is on the rise, and a critical evaluation of their safety and efficacy is required. The purpose of this study was to determine whether commercially available botanicals directly affect the primary brain enzymes responsible for gamma-a...

journal_title：Canadian journal of physiology and pharmacology

authors： Awad R,Levac D,Cybulska P,Merali Z,Trudeau VL,Arnason JT

更新日期：2007-09-01 00:00:00

abstract：:Heme oxygenase (HO) has a central role in cellular antioxidant defences and vascular protection, and it may mediate pleiotropic actions of drugs used in cardiovascular therapy. We investigated whether long-term use of statins upregulates HO activity and increases carbon monoxide (CO) and bilirubin levels in vivo. Adul...

journal_title：Canadian journal of physiology and pharmacology

authors： Muchova L,Wong RJ,Hsu M,Morioka I,Vitek L,Zelenka J,Schröder H,Stevenson DK

更新日期：2007-08-01 00:00:00

abstract：:The airway smooth muscle from asthmatic airways produces increased amounts and an altered composition of extracellular matrix proteins. The extracellular matrix can in turn influence the phenotype and function of airway smooth muscle cells, affecting the biochemical, geometric, and mechanical properties of the airway ...

journal_title：Canadian journal of physiology and pharmacology

authors： Tran T,Halayko AJ

更新日期：2007-07-01 00:00:00

abstract：:The beneficial hypolipidemic and antioxidant influences of the dietary spice compounds curcumin and capsaicin were evaluated. Curcumin, capsaicin, or their combination were included in the diet of high-(30%)-fat-fed rats for 8 weeks. Dietary high-fat-induced hypertriglyceridemia was countered by dietary curcumin, caps...

journal_title：Canadian journal of physiology and pharmacology

authors： Manjunatha H,Srinivasan K

更新日期：2007-06-01 00:00:00

abstract：:D-Serine, a recently identified gliotransmitter, serves as an endogenous coagonist binding to the glycine site of N-methyl-D-aspartate (NMDA) receptors. However, it is not clear whether this native ligand is able to bind to and modulate alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionate (AMPA) receptors. In the pre...

journal_title：Canadian journal of physiology and pharmacology

authors： Gong XQ,Zabek RL,Bai D

更新日期：2007-05-01 00:00:00